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Gene APC
Variant S1356fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC S1356fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1356 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1356fs has not been characterized, however, due to the effects of other truncation mutations downstream of S1356 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC S1356fs

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Transcript NM_000038.6
gDNA chr5:g.(112839659_112839660)
cDNA c.(4066_4065)
Protein p.S1356fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407453.1 chr5:g.(112839836_112839837) c.(4066_4065) p.S1356fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112839659_112839660) c.(4066_4065) p.S1356fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112839659_112839660) c.(4066_4065) p.S1356fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112839659_112839660) c.(4066_4065) p.S1356fs RefSeq GRCh38/hg38
NM_001354901.1 chr5:g.(112839836_112839837) c.(4066_4065) p.S1356fs RefSeq GRCh38/hg38
NM_001354897.2 chr5:g.(112839629_112839630) c.(4066_4065) p.S1356fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112839659_112839660) c.(4066_4065) p.S1356fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112839659_112839660) c.(4066_4065) p.S1356fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112839659_112839660) c.(4066_4065) p.S1356fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112839659_112839660) c.(4066_4065) p.S1356fs RefSeq GRCh38/hg38
NM_001354901.2 chr5:g.(112839836_112839837) c.(4066_4065) p.S1356fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112839659_112839660) c.(4066_4065) p.S1356fs RefSeq GRCh38/hg38
NM_001354897.1 chr5:g.(112839629_112839630) c.(4066_4065) p.S1356fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112839659_112839660) c.(4066_4065) p.S1356fs RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries