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Gene APC
Variant R2525C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC R2525C lies within a region of the APC protein necessary for interaction with DLG1 (UniProt.org). R2525C has been identified in sequencing studies (PMID: 33279946), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

APC mutant APC R2525C

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Transcript NM_000038.6
gDNA chr5:g.112843167C>T
cDNA c.7573C>T
Protein p.R2525C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354900.1 chr5:g.112843290_112843292delAGAinsTGT c.7573_7575delAGAinsTGT p.R2525C RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112843167C>T c.7573C>T p.R2525C RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112843167C>T c.7573C>T p.R2525C RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112843167C>T c.7573C>T p.R2525C RefSeq GRCh38/hg38
NM_001127511 chr5:g.112843221_112843223delAGGinsTGT c.7573_7575delAGGinsTGT p.R2525C RefSeq GRCh38/hg38
NM_001127511.2 chr5:g.112843221_112843223delAGGinsTGT c.7573_7575delAGGinsTGT p.R2525C RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112843167C>T c.7573C>T p.R2525C RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112843167C>T c.7573C>T p.R2525C RefSeq GRCh38/hg38
NM_001127511.3 chr5:g.112843221_112843223delAGGinsTGT c.7573_7575delAGGinsTGT p.R2525C RefSeq GRCh38/hg38
NM_000038 chr5:g.112843167C>T c.7573C>T p.R2525C RefSeq GRCh38/hg38
NM_001354900.2 chr5:g.112843290_112843292delAGAinsTGT c.7573_7575delAGAinsTGT p.R2525C RefSeq GRCh38/hg38
NM_001127510 chr5:g.112843167C>T c.7573C>T p.R2525C RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112843167C>T c.7573C>T p.R2525C RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112843167C>T c.7573C>T p.R2525C RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References