TP53 D281N
Gene Variant Detail

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Gene TP53
Variant D281N
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 D281N lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). D281N is associated with decreased induction of PUMA, BAX, and p21 expression in a patient sample (PMID: 19850740) and fails to induce apoptosis in Tp53-null cells in culture (PMID: 30840781), and therefore, is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 D281N

TP53 mutant TP53 inact mut TP53 D281N

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Transcript NM_000546.6
gDNA chr17:g.7673779C>T
cDNA c.841G>A
Protein p.D281N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.2 chr17:g.7673779C>T c.841G>A p.D281N RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673779C>T c.841G>A p.D281N RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673779C>T c.841G>A p.D281N RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673779C>T c.841G>A p.D281N RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7673779C>T c.841G>A p.D281N RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673779C>T c.841G>A p.D281N RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7673779C>T c.841G>A p.D281N RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673779C>T c.841G>A p.D281N RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673779C>T c.841G>A p.D281N RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673779C>T c.841G>A p.D281N RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673779C>T c.841G>A p.D281N RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7673779C>T c.841G>A p.D281N RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673779C>T c.841G>A p.D281N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries