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Gene TP53
Variant R267P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 R267P lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). R267P results in impaired transcriptional activation of CCNA2 and CHEK1 (PMID: 28394262), but partially retains transcriptional activation of AXL and p21 in cell culture, leads to increased cell proliferation in culture but suppresses tumor formation in animal models (PMID: 22989750), and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 R267P

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Transcript NM_000546.6
gDNA chr17:g.7673820C>G
cDNA c.800G>C
Protein p.R267P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.2 chr17:g.7673820C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001276761.3 chr17:g.7673703C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673820C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673820C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001407265.1 chr17:g.7673703C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001276696.3 chr17:g.7673703C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001407263.1 chr17:g.7673703C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7673820C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001407269.1 chr17:g.7673703C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673820C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7673820C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673820C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673820C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673820C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001407271.1 chr17:g.7673703C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001126118.2 chr17:g.7673703C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673820C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673820C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7673820C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001276695.3 chr17:g.7673703C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001276760.3 chr17:g.7673703C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673820C>G c.800G>C p.R267P RefSeq GRCh38/hg38
NM_001407267.1 chr17:g.7673703C>G c.800G>C p.R267P RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References