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Gene APC
Variant R374W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC R374W does not lie within any known functional domains of the Apc protein (UniProt.org). R374W has been identified in sequencing studies (PMID: 29684080), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Sep 2024).
Associated Drug Resistance
Category Variants Paths

APC mutant APC R374W

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Transcript NM_000038.6
gDNA chr5:g.112819152C>T
cDNA c.1120C>T
Protein p.R374W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407450.1 chr5:g.112819152C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001354896.1 chr5:g.112819152C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001407447.1 chr5:g.112819152C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001407470.1 chr5:g.112837563_112837565delAGAinsTGG c.1120_1122delAGAinsTGG p.R374W RefSeq GRCh38/hg38
NM_001407452.1 chr5:g.112819236_112819238delCGTinsTGG c.1120_1122delCGTinsTGG p.R374W RefSeq GRCh38/hg38
NM_001407455.1 chr5:g.112823321C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001407451.1 chr5:g.112819227_112819229delAGAinsTGG c.1120_1122delAGAinsTGG p.R374W RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112819152C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001407449.1 chr5:g.112819152C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001354899.1 chr5:g.112819236_112819238delCGTinsTGG c.1120_1122delCGTinsTGG p.R374W RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112819152C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001407448.1 chr5:g.112819152C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001127510 chr5:g.112819152C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112819152C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001354898.2 chr5:g.112819227_112819229delAGAinsTGG c.1120_1122delAGAinsTGG p.R374W RefSeq GRCh38/hg38
NM_000038 chr5:g.112819152C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001354906.2 chr5:g.112837563_112837565delAGAinsTGG c.1120_1122delAGAinsTGG p.R374W RefSeq GRCh38/hg38
NM_001407456.1 chr5:g.112823321C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001354898.1 chr5:g.112819227_112819229delAGAinsTGG c.1120_1122delAGAinsTGG p.R374W RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112819152C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001354896.2 chr5:g.112819152C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001354899.2 chr5:g.112819236_112819238delCGTinsTGG c.1120_1122delCGTinsTGG p.R374W RefSeq GRCh38/hg38
NM_001354906.1 chr5:g.112837563_112837565delAGAinsTGG c.1120_1122delAGAinsTGG p.R374W RefSeq GRCh38/hg38
NM_001407457.1 chr5:g.112823321C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112819152C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112819152C>T c.1120C>T p.R374W RefSeq GRCh38/hg38
NM_001407454.1 chr5:g.112823321C>T c.1120C>T p.R374W RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries