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Gene CDKN2A
Variant D74G
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CDKN2A D74G does not lie within any known functional domains of the Cdkn2a protein (UniProt.org). D74G has been identified in the scientific literature (PMID: 30423298), but has not been biochemically characterized and therefore, its effect on Cdkn2a protein function is unknown (PubMed, May 2024).
Associated Drug Resistance
Category Variants Paths

CDKN2A mutant CDKN2A D74G

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Transcript NM_000077.5
gDNA chr9:g.21971138T>C
cDNA c.221A>G
Protein p.D74G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047422596.1 chr9:g.21970985T>C c.221A>G p.D74G RefSeq GRCh38/hg38
XM_011517676.2 chr9:g.21971138T>C c.221A>G p.D74G RefSeq GRCh38/hg38
XM_047422597.1 chr9:g.21970985T>C c.221A>G p.D74G RefSeq GRCh38/hg38
NM_001195132.2 chr9:g.21971138T>C c.221A>G p.D74G RefSeq GRCh38/hg38
NM_001195132.1 chr9:g.21971138T>C c.221A>G p.D74G RefSeq GRCh38/hg38
NM_001363763.2 chr9:g.21970985T>C c.221A>G p.D74G RefSeq GRCh38/hg38
XM_011517675.3 chr9:g.21971138T>C c.221A>G p.D74G RefSeq GRCh38/hg38
NM_000077.4 chr9:g.21971138T>C c.221A>G p.D74G RefSeq GRCh38/hg38
NM_000077.5 chr9:g.21971138T>C c.221A>G p.D74G RefSeq GRCh38/hg38
XM_011517676.3 chr9:g.21971138T>C c.221A>G p.D74G RefSeq GRCh38/hg38
XM_011517675.2 chr9:g.21971138T>C c.221A>G p.D74G RefSeq GRCh38/hg38
XM_047422598.1 chr9:g.21970985T>C c.221A>G p.D74G RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References