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Gene PTEN
Variant T277A
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions PTEN T277A lies within the C2 tensin-type domain of the Pten protein (UniProt.org). T277A results in similar phosphatase activity to wild-type Pten in an in vitro assay (PMID: 28263967), and in cultured cells and a yeast assay (PMID: 36543932) but results in reduced protein stability (PMID: 28263967, PMID: 36543932), altered subcellular localization (PMID: 36543932), decreased suppression of Akt phosphorylation and Pip3 levels, increased cell proliferation and migration, and inhibition of Pten membrane and nuclear localization in cell culture (PMID: 28263967).
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN T277A

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Transcript NM_000314.8
gDNA chr10:g.87960921A>G
cDNA c.829A>G
Protein p.T277A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.8 chr10:g.87960921A>G c.829A>G p.T277A RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87960921A>G c.829A>G p.T277A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References