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Gene APC
Variant T1445fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC T1445fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1445 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1445fs has not been characterized, however, due to the effects of other truncation mutations downstream of T1445 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC T1445fs

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Transcript NM_000038.6
gDNA chr5:g.(112839926_112839927)
cDNA c.(4333_4332)
Protein p.T1445fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510.3 chr5:g.(112839926_112839927) c.(4333_4332) p.T1445fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112839926_112839927) c.(4333_4332) p.T1445fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112839926_112839927) c.(4333_4332) p.T1445fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112839926_112839927) c.(4333_4332) p.T1445fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112839926_112839927) c.(4333_4332) p.T1445fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112839926_112839927) c.(4333_4332) p.T1445fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112839926_112839927) c.(4333_4332) p.T1445fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112839926_112839927) c.(4333_4332) p.T1445fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112839926_112839927) c.(4333_4332) p.T1445fs RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Protein Effect Treatment Approaches
APC T1445fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor