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Gene APC
Variant T1556fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC T1556fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1556 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1556fs has not been characterized, however, due to the effects of other truncation mutations downstream of T1556 (PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC T1556fs

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Transcript NM_000038.6
gDNA chr5:g.(112840259_112840260)
cDNA c.(4666_4665)
Protein p.T1556fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038 chr5:g.(112840259_112840260) c.(4666_4665) p.T1556fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112840259_112840260) c.(4666_4665) p.T1556fs RefSeq GRCh38/hg38
NM_001354902.2 chr5:g.(112840532_112840533) c.(4666_4665) p.T1556fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112840259_112840260) c.(4666_4665) p.T1556fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112840259_112840260) c.(4666_4665) p.T1556fs RefSeq GRCh38/hg38
NM_001354900.1 chr5:g.(112840382_112840383) c.(4666_4665) p.T1556fs RefSeq GRCh38/hg38
NM_001354900.2 chr5:g.(112840382_112840383) c.(4666_4665) p.T1556fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112840259_112840260) c.(4666_4665) p.T1556fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112840259_112840260) c.(4666_4665) p.T1556fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112840259_112840260) c.(4666_4665) p.T1556fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112840259_112840260) c.(4666_4665) p.T1556fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112840259_112840260) c.(4666_4665) p.T1556fs RefSeq GRCh38/hg38
NM_001354902.1 chr5:g.(112840532_112840533) c.(4666_4665) p.T1556fs RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
APC T1556fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E853* APC T1556fs