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Gene APC
Variant T1459fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC T1459fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1459 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1459fs has not been characterized, however, due to the effects of other truncation mutations downstream of T1459 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC T1459fs

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Transcript NM_000038.6
gDNA chr5:g.(112839968_112839969)
cDNA c.(4375_4374)
Protein p.T1459fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510 chr5:g.(112839968_112839969) c.(4375_4374) p.T1459fs RefSeq GRCh38/hg38
NM_001354899.1 chr5:g.(112840052_112840053) c.(4375_4374) p.T1459fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112839968_112839969) c.(4375_4374) p.T1459fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112839968_112839969) c.(4375_4374) p.T1459fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112839968_112839969) c.(4375_4374) p.T1459fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112839968_112839969) c.(4375_4374) p.T1459fs RefSeq GRCh38/hg38
NM_001354899.2 chr5:g.(112840052_112840053) c.(4375_4374) p.T1459fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112839968_112839969) c.(4375_4374) p.T1459fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112839968_112839969) c.(4375_4374) p.T1459fs RefSeq GRCh38/hg38
NM_001354904.2 chr5:g.(112840346_112840347) c.(4375_4374) p.T1459fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112839968_112839969) c.(4375_4374) p.T1459fs RefSeq GRCh38/hg38
NM_001354904.1 chr5:g.(112840346_112840347) c.(4375_4374) p.T1459fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112839968_112839969) c.(4375_4374) p.T1459fs RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
APC T1459fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E941* APC T1459fs