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Gene CDKN2A
Variant V28_E33del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions CDKN2A V28_E33del results in the deletion of six amino acids in ANK repeat 1 of the Cdkn2a protein from amino acids 28 to 33 (UniProt.org). V28_E33del has been identified in the scientific literature (PMID: 36628896), but has not been biochemically characterized and therefore, its effect on Cdkn2a protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

CDKN2A mutant CDKN2A V28_E33del

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Transcript NM_000077.5
gDNA chr9:g.21974733_21974750del18
cDNA c.83_100del18
Protein p.V28_E33delVRALLE
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011517676.2 chr9:g.21974733_21974750del18 c.83_100del18 p.V28_E33del RefSeq GRCh38/hg38
NM_000077.4 chr9:g.21974733_21974750del18 c.83_100del18 p.V28_E33del RefSeq GRCh38/hg38
NM_058197.4 chr9:g.21974733_21974750del18 c.83_100del18 p.V28_E33del RefSeq GRCh38/hg38
NM_001195132.1 chr9:g.21974733_21974750del18 c.83_100del18 p.V28_E33del RefSeq GRCh38/hg38
NM_058195.4 chr9:g.21994233_21994250del18 c.82_99del18 p.P28_E33delPRLTGE RefSeq GRCh38/hg38
XM_011517675.2 chr9:g.21974733_21974750del18 c.83_100del18 p.V28_E33del RefSeq GRCh38/hg38
XM_011517675.3 chr9:g.21974733_21974750del18 c.83_100del18 p.V28_E33delVRALLE RefSeq GRCh38/hg38
NM_058197.5 chr9:g.21974733_21974750del18 c.83_100del18 p.V28_E33delVRALLE RefSeq GRCh38/hg38
XM_047422597.1 chr9:g.21971108_21971125del18 c.82_99del18 p.T28_D33delTRPVHD RefSeq GRCh38/hg38
XM_047422596.1 chr9:g.21971108_21971125del18 c.82_99del18 p.T28_D33delTRPVHD RefSeq GRCh38/hg38
XM_047422598.1 chr9:g.21971108_21971125del18 c.82_99del18 p.T28_D33delTRPVHD RefSeq GRCh38/hg38
NM_001363763.2 chr9:g.21971108_21971125del18 c.82_99del18 p.T28_D33delTRPVHD RefSeq GRCh38/hg38
XM_011517676.3 chr9:g.21974733_21974750del18 c.83_100del18 p.V28_E33delVRALLE RefSeq GRCh38/hg38
NM_000077.5 chr9:g.21974733_21974750del18 c.83_100del18 p.V28_E33delVRALLE RefSeq GRCh38/hg38
NM_001195132.2 chr9:g.21974733_21974750del18 c.83_100del18 p.V28_E33delVRALLE RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References