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Gene | PIK3CA |
Variant | C90Y |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | PIK3CA C90Y lies within the PI3K-ABD domain of the Pik3ca protein (UniProt.org). C90Y results in Akt, S6, and Erk1/2 phosphorylation, proliferation, and migration similar to wild-type Pik3ca in cultured cells (PMID: 29975751), and therefore, is predicted to have no effect on Pik3ca protein function. |
Associated Drug Resistance | |
Category Variants Paths |
PIK3CA mutant PIK3CA C90Y |
Transcript | NM_006218.4 |
gDNA | chr3:g.179199094G>A |
cDNA | c.269G>A |
Protein | p.C90Y |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_011512894.2 | chr3:g.179199094G>A | c.269G>A | p.C90Y | RefSeq | GRCh38/hg38 |
XM_006713658.5 | chr3:g.179199094G>A | c.269G>A | p.C90Y | RefSeq | GRCh38/hg38 |
XM_006713658.4 | chr3:g.179199094G>A | c.269G>A | p.C90Y | RefSeq | GRCh38/hg38 |
NM_006218.4 | chr3:g.179199094G>A | c.269G>A | p.C90Y | RefSeq | GRCh38/hg38 |
NM_006218.3 | chr3:g.179199094G>A | c.269G>A | p.C90Y | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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