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Gene PIK3CA
Variant E453_D454del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA E453_D454del results in the deletion of two amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 453 to 454 (UniProt.org). E453_D454del has been identified in sequencing studies (PMID: 30393068), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA E453_D454del

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Transcript NM_006218.4
gDNA chr3:g.179210291_179210296delGAAGAT
cDNA c.1357_1362delGAAGAT
Protein p.E453_D454del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179210291_179210296delGAAGAT c.1357_1362delGAAGAT p.E453_D454del RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210291_179210296delGAAGAT c.1357_1362delGAAGAT p.E453_D454del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries