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Gene PIK3CA
Variant E453_P466del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA E453_P466del results in the deletion of 14 amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 453 to 466 (UniProt.org). E453_P466del has been identified in sequencing studies (PMID: 30393068), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA E453_P466del

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Transcript NM_006218.4
gDNA chr3:g.179210291_179210332del42
cDNA c.1357_1398del42
Protein p.E453_P466del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.5 chr3:g.179210291_179210332del42 c.1357_1398del42 p.E453_P466del RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210291_179210332del42 c.1357_1398del42 p.E453_P466del RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries