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Gene PIK3CA
Variant E453_T462del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA E453_T462del results in the deletion of ten amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 453 to 462 (UniProt.org). E453_T462del has been identified in sequencing studies (PMID: 30393068), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA E453_T462del

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Transcript NM_006218.4
gDNA chr3:g.179210292_179210321del30
cDNA c.1358_1387del30
Protein p.E453_T462del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.3 chr3:g.179210292_179210321del30 c.1358_1387del30 p.E453_T462del RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210292_179210321del30 c.1358_1387del30 p.E453_T462del RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210292_179210321del30 c.1358_1387del30 p.E453_T462del RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210292_179210321del30 c.1358_1387del30 p.E453_T462del RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210292_179210321del30 c.1358_1387del30 p.E453_T462del RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References