Gene Variant Detail

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Gene PIK3CA
Variant H419_L422del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA H419_L422del results in the deletion of four amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 419 to 422 (UniProt.org). H419_L422del has not been characterized in the scientific literature and therefore, its effect on Pik3ca protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA H419_L422del

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Transcript NM_006218.4
gDNA chr3:g.179210189_179210200del12
cDNA c.1255_1266del12
Protein p.H419_L422del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179210189_179210200del12 c.1255_1266del12 p.H419_L422del RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210189_179210200del12 c.1255_1266del12 p.H419_L422del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
PIK3CA H419_L422del unknown