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Gene PIK3CA
Variant G463_N465delinsD
Impact List indel
Protein Effect unknown
Gene Variant Descriptions PIK3CA G463_N465delinsD results in the deletion of three amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 463 to 465, combined with the insertion of an aspartic acid (D) at the same site (UniProt.org). G463_N465delinsD has not been characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA G463_N465delinsD

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Transcript NM_006218.4
gDNA chr3:g.179210322_179210327delGATCAA
cDNA c.1388_1393delGATCAA
Protein p.G463_N465delinsD
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.3 chr3:g.179210322_179210327delGATCAA c.1388_1393delGATCAA p.G463_N465delinsD RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210322_179210327delGATCAA c.1388_1393delGATCAA p.G463_N465delinsD RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210322_179210327delGATCAA c.1388_1393delGATCAA p.G463_N465delinsD RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210322_179210327delGATCAA c.1388_1393delGATCAA p.G463_N465delinsD RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210322_179210327delGATCAA c.1388_1393delGATCAA p.G463_N465delinsD RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References