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Gene TP53
Variant G245R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 G245R is a hotspot mutation that lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). G245R has been identified in the scientific literature (PMID: 17041903, PMID: 31073076, PMID: 32380900), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 G245R

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Transcript NM_000546.6
gDNA chr17:g.7674230C>G
cDNA c.733G>C
Protein p.G245R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_000546 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674230C>G c.733G>C p.G245R RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries