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TP53 R175C - Gene Variant Detail

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Gene TP53
Variant R175C
Impact List missense
Protein Effect no effect
Gene Variant Descriptions TP53 R175C is a hotspot mutation that lies within the DNA binding domain of the Tp53 protein (PMID: 22713868). R175C retains wild-type Tp53 function in apoptosis and cell cycle assays (PMID: 9632751, PMID: 24665023).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 R175X TP53 R175C

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Transcript NM_000546.6
gDNA chr17:g.7675089G>A
cDNA c.523C>T
Protein p.R175C
Source Database RefSeq
Genome Build GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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