CHEK2 R406Vfs*8
Gene Variant Detail

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Gene CHEK2
Variant R406Vfs*8
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions CHEK2 R406Vfs*8 indicates a shift in the reading frame starting at amino acid 406 and terminating 8 residues downstream causing a premature truncation of the 543 amino acid Chek2 protein (UniProt.org). R406Vfs*8 has not been characterized in the scientific literature and therefore, its effect on Chek2 protein function is unknown (PubMed, Apr 2026).
Associated Drug Resistance
Category Variants Paths

CHEK2 mutant CHEK2 R406Vfs*8

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Transcript NM_007194.4
gDNA chr22:g.28695754delG
cDNA c.1216delC
Protein p.R406Vfs*8
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011529840.4 chr22:g.28695825_28695826insATGGGGGGGGGGGGGGGGGGAC c.1215_1216insGTCCCCCCCCCCCCCCCCCCAT p.R406Vfs*8 RefSeq GRCh38/hg38
NM_007194.3 chr22:g.28695754delG c.1216delC p.R406Vfs*8 RefSeq GRCh38/hg38
NM_007194.4 chr22:g.28695754delG c.1216delC p.R406Vfs*8 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
CHEK2 R406Vfs*8 unknown Olaparib