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Gene RAD51C
Variant G162Efs*9
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions RAD51C G162Efs*9 indicates a shift in the reading frame starting at amino acid 162 and terminating nine residues downstream causing a premature truncation of the 376 amino acid Rad51c protein (UniProt.org). G162Efs*9 has not been characterized however, due to the effects of other truncation mutations downstream of G162 (PMID: 28588062), is predicted to lead to a loss of Rad51c protein function.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C G162Efs*9

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Transcript NM_058216.3
gDNA chr17:g.58696773delG
cDNA c.485delG
Protein p.G162Efs*9
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722001.5 chr17:g.58696773delG c.485delG p.G162Efs*9 RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58696773delG c.485delG p.G162Efs*9 RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58696773delG c.485delG p.G162Efs*9 RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58696773delG c.485delG p.G162Efs*9 RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58696773delG c.485delG p.G162Efs*9 RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58696773delG c.485delG p.G162Efs*9 RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58696773delG c.485delG p.G162Efs*9 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References