TP53 R273Y - Gene Variant Detail

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Gene TP53
Variant R273Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 R273Y is a hotspot mutation that lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). R273Y has been identified in the scientific literature (PMID: 29150975, PMID: 29026176), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2025).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 R273X TP53 R273Y

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Transcript NM_000546.6
gDNA chr17:g.7673802_7673803delCGinsTA
cDNA c.817_818delCGinsTA
Protein p.R273Y
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.