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Gene FLT3
Variant E598_F612dup
Impact List duplication
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 E598_F612dup indicates the insertion of 15 duplicate amino acids, glutamic acid (E)-598 through phenylalanine (F)-612, in the juxtamembrane domain of the Flt3 protein (PMID: 14759363). E598_F612dup has not been biochemically characterized, but can be predicted to lead to activation of Flt3 based on the effects of other Flt3 internal tandem duplication (ITD) mutations (PMID: 12970773, PMID: 9737679, PMID: 11090077).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 exon 14 ins FLT3 E598_F612dup

FLT3 mutant FLT3 exon14 FLT3 exon 14 ins FLT3 E598_F612dup

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Transcript NM_004119.3
gDNA chr13:g.28034083_28034127
cDNA c.1792_1836
Protein p.E598_F612
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28034083_28034127 c.1792_1836 p.E598_F612 RefSeq GRCh38/hg38
NM_004119 chr13:g.28033992_28033993insAAACTCAAGGTTCTCCCTAGGAAACTCCCACTTAAGGTCATACTC c.1838-1_1838insAGTATGACCTTAAGTGGGAGTTTCCTAGGGAGAACCTTGAGTTTG p.E598_F612dup RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References