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Gene FLT3
Variant F612_G613insQGFYVDFREYEYDLKWEFPRENLEF
Impact List insertion
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 F612_G613insQGFYVDFREYEYDLKWEFPRENLEF results in the insertion of 25 amino acids in the juxtamembrane domain of the Flt3 protein between amino acids 612 and 613 (PMID: 14759363). F612_G613insQGFYVDFREYEYDLKWEFPRENLEF has not been biochemically characterized, but can be predicted to lead to activation of Flt3 based on the effects of other Flt3 internal tandem duplication (ITD) mutations (PMID: 12970773, PMID: 9737679, PMID: 11090077).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 exon 14 ins FLT3 F612_G613insQGFYVDFREYEYDLKWEFPRENLEF

FLT3 mutant FLT3 exon14 FLT3 exon 14 ins FLT3 F612_G613insQGFYVDFREYEYDLKWEFPRENLEF

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Transcript NM_004119.3
gDNA chr13:g.28033992_28033993insAAACTCAAGGTTCTCCCTAGGAAACTCCCACTTAAGGTCATACTCATACTCCCTAAAGTCTACATAAAAACCTTG
cDNA c.1838-2_1838-1insCAAGGTTTTTATGTAGACTTTAGGGAGTATGAGTATGACCTTAAGTGGGAGTTTCCTAGGGAGAACCTTGAGTTT
Protein p.F612_G613insQGFYVDFREYEYDLKWEFPRENLEF
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28033992_28033993insAAACTCAAGGTTCTCCCTAGGAAACTCCCACTTAAGGTCATACTCATACTCCCTAAAGTCTACATAAAAACCTTG c.1838-2_1838-1insCAAGGTTTTTATGTAGACTTTAGGGAGTATGAGTATGACCTTAAGTGGGAGTTTCCTAGGGAGAACCTTGAGTTT p.F612_G613insQGFYVDFREYEYDLKWEFPRENLEF RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28033992_28033993insAAACTCAAGGTTCTCCCTAGGAAACTCCCACTTAAGGTCATACTCATACTCCCTAAAGTCTACATAAAAACCTTG c.1838-2_1838-1insCAAGGTTTTTATGTAGACTTTAGGGAGTATGAGTATGACCTTAAGTGGGAGTTTCCTAGGGAGAACCTTGAGTTT p.F612_G613insQGFYVDFREYEYDLKWEFPRENLEF RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries