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Gene FLT3
Variant Y597_E598insAGSSDNEYFYVDFREY
Impact List insertion
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 Y597_E598insAGSSDNEYFYVDFREY results in the insertion of 16 amino acids in the juxtamembrane domain of the Flt3 protein between amino acids 597 and 598 (PMID: 14759363). Y597_E598insAGSSDNEYFYVDFREY has not been biochemically characterized, but can be predicted to lead to activation of Flt3 based on the effects of other Flt3 internal tandem duplication (ITD) mutations (PMID: 12970773, PMID: 9737679, PMID: 11090077).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 exon 14 ins FLT3 Y597_E598insAGSSDNEYFYVDFREY

FLT3 mutant FLT3 exon14 FLT3 exon 14 ins FLT3 Y597_E598insAGSSDNEYFYVDFREY

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Transcript NM_004119.3
gDNA chr13:g.28034130_28034131insCTCCCTAAAGTCTACATAAAAATACTCGTTGTCGCTGCTACCTGCATA
cDNA c.1792_1793insCAGGTAGCAGCGACAACGAGTATTTTTATGTAGACTTTAGGGAGTATG
Protein p.Y597_E598insAGSSDNEYFYVDFREY
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28034130_28034131insCTCCCTAAAGTCTACATAAAAATACTCGTTGTCGCTGCTACCTGCATA c.1792_1793insCAGGTAGCAGCGACAACGAGTATTTTTATGTAGACTTTAGGGAGTATG p.Y597_E598insAGSSDNEYFYVDFREY RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28034130_28034131insCTCCCTAAAGTCTACATAAAAATACTCGTTGTCGCTGCTACCTGCATA c.1792_1793insCAGGTAGCAGCGACAACGAGTATTTTTATGTAGACTTTAGGGAGTATG p.Y597_E598insAGSSDNEYFYVDFREY RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
FLT3 Y597_E598insAGSSDNEYFYVDFREY gain of function - predicted FLT3 Inhibitor