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Gene IDH2
Variant V351I
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions IDH2 V351I does not lie within any known functional domains of the Idh2 protein (UniProt.org). V351I confers resistance to an IDH2 inhibitor in the presence of IDH2 R140Q, but does not lead to increased production of the oncometabolite 2HG (R(-)-2-hydroxyglutarate) in cell culture (PMID: 36222845), and therefore, is predicted to have no effect on Idh2 protein function.
Associated Drug Resistance Y
Category Variants Paths

IDH2 mutant IDH2 V351I

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Transcript NM_002168.4
gDNA chr15:g.90085304C>T
cDNA c.1051G>A
Protein p.V351I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002168.3 chr15:g.90085304C>T c.1051G>A p.V351I RefSeq GRCh38/hg38
NM_002168.4 chr15:g.90085304C>T c.1051G>A p.V351I RefSeq GRCh38/hg38
NM_001289910.1 chr15:g.90084878_90084880delGTGinsATC c.1051_1053delGTGinsATC p.V351I RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries