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Gene IDH2
Variant V351I
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions IDH2 V351I does not lie within any known functional domains of the Idh2 protein (UniProt.org). V351I confers resistance to an IDH2 inhibitor in the presence of IDH2 R140Q, but does not lead to increased production of the oncometabolite 2HG (R(-)-2-hydroxyglutarate) in cell culture (PMID: 36222845), and therefore, is predicted to have no effect on Idh2 protein function.
Associated Drug Resistance Y
Category Variants Paths

IDH2 mutant IDH2 V351I

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Transcript NM_002168.4
gDNA chr15:g.90085304C>T
cDNA c.1051G>A
Protein p.V351I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002168.3 chr15:g.90085304C>T c.1051G>A p.V351I RefSeq GRCh38/hg38
NM_001289910.1 chr15:g.90084878_90084880delGTGinsATC c.1051_1053delGTGinsATC p.V351I RefSeq GRCh38/hg38
NM_002168.4 chr15:g.90085304C>T c.1051G>A p.V351I RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References