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Gene IDH2
Variant T352A
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions IDH2 T352A does not lie within any known functional domains of the Idh2 protein (UniProt.org). T352A confers resistance to an IDH2 inhibitor in the presence of IDH2 R140Q, but does not lead to increased production of the oncometabolite 2HG (R(-)-2-hydroxyglutarate) in cell culture (PMID: 36222845), and therefore, is predicted to have no effect on Idh2 protein function.
Associated Drug Resistance Y
Category Variants Paths

IDH2 mutant IDH2 T352A

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Transcript NM_002168.4
gDNA chr15:g.90085301T>C
cDNA c.1054A>G
Protein p.T352A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002168.3 chr15:g.90085301T>C c.1054A>G p.T352A RefSeq GRCh38/hg38
NM_002168.4 chr15:g.90085301T>C c.1054A>G p.T352A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
IDH2 T352A no effect - predicted
IDH2 R140Q IDH2 T352A