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IDH2 L449V - Gene Variant Detail

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Gene IDH2
Variant L449V
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions IDH2 L449V does not lie within any known functional domains of the Idh2 protein (UniProt.org). L449V does not lead to increased production of the oncometabolite 2HG (R(-)-2-hydroxyglutarate) in cell culture (PMID: 36222845), and therefore, is predicted to have no effect on Idh2 protein function.
Associated Drug Resistance
Category Variants Paths

IDH2 mutant IDH2 L449V

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Transcript NM_002168.4
gDNA chr15:g.90084280G>C
cDNA c.1345C>G
Protein p.L449V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002168.3 chr15:g.90084280G>C c.1345C>G p.L449V RefSeq GRCh38/hg38
NM_002168.4 chr15:g.90084280G>C c.1345C>G p.L449V RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References