Gene Variant Detail

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Gene APC
Variant T1487Ifs*21
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC T1487Ifs*21 indicates a shift in the reading frame starting at amino acid 1487 and terminating 21 residues downstream causing a premature truncation of the 2843 amino acid Apc protein (UniProt.org). T1487Ifs*21 has not been characterized, however, due to the effects of other truncation mutations downstream of T1487 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC T1487fs APC T1487Ifs*21

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Transcript NM_000038.6
gDNA chr5:g.112840052_112840053dupTA
cDNA c.4458_4459dupTA
Protein p.T1487Ifs*21
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510.3 chr5:g.112840052_112840053dupTA c.4458_4459dupTA p.T1487Ifs*21 RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112840052_112840053dupTA c.4458_4459dupTA p.T1487Ifs*21 RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112840052_112840053dupTA c.4458_4459dupTA p.T1487Ifs*21 RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112840052_112840053dupTA c.4458_4459dupTA p.T1487Ifs*21 RefSeq GRCh38/hg38
NM_001407446.1 chr5:g.112839969_112839970insTCCCCCCCCCCCCCCCAAAA c.4459_4460insTCCCCCCCCCCCCCCCAAAA p.T1487Ifs*21 RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112840052_112840053dupTA c.4458_4459dupTA p.T1487Ifs*21 RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112840052_112840053dupTA c.4458_4459dupTA p.T1487Ifs*21 RefSeq GRCh38/hg38
NM_001354905.2 chr5:g.112840533_112840534insTCCCCCCCCCCCCCCCCCCCCCAAA c.4459_4460insTCCCCCCCCCCCCCCCCCCCCCAAA p.T1487Ifs*21 RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112840052_112840053dupTA c.4458_4459dupTA p.T1487Ifs*21 RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries