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Gene PIK3CA
Variant L452_G460del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA L452_G460del results in the deletion of nine amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 452 to 460 (UniProt.org). L452_G460del has been identified in the scientific literature (PMID: 28528867), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA L452_G460del

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Transcript NM_006218.4
gDNA chr3:g.179210288_179210314del27
cDNA c.1354_1380del27
Protein p.L452_G460delLEDLLNPIG
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.4 chr3:g.179210288_179210314del27 c.1354_1380del27 p.L452_G460del RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210288_179210314del27 c.1354_1380del27 p.L452_G460del RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210288_179210314del27 c.1354_1380del27 p.L452_G460delLEDLLNPIG RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210288_179210314del27 c.1354_1380del27 p.L452_G460del RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210288_179210314del27 c.1354_1380del27 p.L452_G460delLEDLLNPIG RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
PIK3CA L452_G460del unknown