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Gene PIK3CA
Variant L452_P458del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA L452_P458del results in the deletion of seven amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 452 to 458 (UniProt.org). L452_P458del has not been characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA L452_P458del

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Transcript NM_006218.4
gDNA chr3:g.179210288_179210308del21
cDNA c.1354_1374del21
Protein p.L452_P458delLEDLLNP
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179210288_179210308del21 c.1354_1374del21 p.L452_P458delLEDLLNP RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210288_179210308del21 c.1354_1374del21 p.L452_P458del RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210288_179210308del21 c.1354_1374del21 p.L452_P458del RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210288_179210308del21 c.1354_1374del21 p.L452_P458delLEDLLNP RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210288_179210308del21 c.1354_1374del21 p.L452_P458del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
PIK3CA L452_P458del unknown