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Gene TP53
Variant A138P
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 A138P lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). A138P results in growth and cell cycle distribution similar to wild-type protein at nonstressed conditions (PMID: 15548685), but rescues TGF-beta-induced apoptosis in cell culture (PMID: 15548685; PMID: 22621932), and demonstrates reduced ability to regulate transcription of Tp53 target genes in culture (PMID: 15548685), and therefore, is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 A138P

TP53 mutant TP53 inact mut TP53 A138P

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Transcript NM_000546.6
gDNA chr17:g.7675200C>G
cDNA c.412G>C
Protein p.A138P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.5 chr17:g.7675200C>G c.412G>C p.A138P RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675200C>G c.412G>C p.A138P RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675200C>G c.412G>C p.A138P RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675200C>G c.412G>C p.A138P RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675200C>G c.412G>C p.A138P RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675200C>G c.412G>C p.A138P RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675200C>G c.412G>C p.A138P RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675200C>G c.412G>C p.A138P RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675200C>G c.412G>C p.A138P RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675200C>G c.412G>C p.A138P RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675200C>G c.412G>C p.A138P RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675200C>G c.412G>C p.A138P RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675200C>G c.412G>C p.A138P RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References