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Gene PIK3CA
Variant P449_L452del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA P449_L452del results in the deletion of four amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 449 to 452 (UniProt.org). P449_L452del has been identified in sequencing studies (PMID: 30393068), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA P449_L452del

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Transcript NM_006218.4
gDNA chr3:g.179210279_179210290del12
cDNA c.1345_1356del12
Protein p.P449_L452delPHGL
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894.2 chr3:g.179210279_179210290del12 c.1345_1356del12 p.P449_L452del RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210279_179210290del12 c.1345_1356del12 p.P449_L452del RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210279_179210290del12 c.1345_1356del12 p.P449_L452delPHGL RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210279_179210290del12 c.1345_1356del12 p.P449_L452del RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210279_179210290del12 c.1345_1356del12 p.P449_L452delPHGL RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries