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Gene TP53
Variant G245fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 G245fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 245 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). G245fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of G245 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 G245fs

TP53 mutant TP53 inact mut TP53 G245fs

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Transcript NM_000546.6
gDNA chr17:g.(7674230_7674231)
cDNA c.(733_732)
Protein p.G245fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112.2 chr17:g.(7674230_7674231) c.(733_732) p.G245fs RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.(7674230_7674231) c.(733_732) p.G245fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7674230_7674231) c.(733_732) p.G245fs RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.(7674230_7674231) c.(733_732) p.G245fs RefSeq GRCh38/hg38
NM_000546.5 chr17:g.(7674230_7674231) c.(733_732) p.G245fs RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.(7674230_7674231) c.(733_732) p.G245fs RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.(7674230_7674231) c.(733_732) p.G245fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7674230_7674231) c.(733_732) p.G245fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7674230_7674231) c.(733_732) p.G245fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7674230_7674231) c.(733_732) p.G245fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7674230_7674231) c.(733_732) p.G245fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7674230_7674231) c.(733_732) p.G245fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7674230_7674231) c.(733_732) p.G245fs RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References