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Gene KMT2A
Variant W838Lfs*9
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions KMT2A W838Lfs*9 indicates a shift in the reading frame starting at amino acid 838 and terminating 9 residues downstream causing a premature truncation of the 3969 amino acid Kmt2a protein (UniProt.org). Due to the loss of all known functional domains (UniProt.org), W838Lfs*9 is predicted to lead to a loss of Kmt2a protein function.
Associated Drug Resistance
Category Variants Paths

KMT2A mutant KMT2A inact mut KMT2A W838Lfs*9

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Transcript NM_005933.4
gDNA chr11:g.118473671dupT
cDNA c.2512dupT
Protein p.W838Lfs*9
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001197104.1 chr11:g.118473671dupT c.2512dupT p.W838Lfs*9 RefSeq GRCh38/hg38
NM_005933.3 chr11:g.118473671dupT c.2512dupT p.W838Lfs*9 RefSeq GRCh38/hg38
NM_005933.4 chr11:g.118473671dupT c.2512dupT p.W838Lfs*9 RefSeq GRCh38/hg38
NM_001197104.2 chr11:g.118473671dupT c.2512dupT p.W838Lfs*9 RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References