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Gene STK11
Variant Y60fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 Y60fs results in a change in the amino acid sequence of the Stk11 protein beginning at aa 60 of 433, likely resulting in premature truncation of the functional protein (UniProt.org). Y60fs has not been characterized however, due to the effects of other truncation mutations downstream of Y60 (PMID: 23612973), is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 Y60fs

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Transcript NM_000455.5
gDNA chr19:g.(1207090_1207091)
cDNA c.(178_177)
Protein p.Y60fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005259617.3 chr19:g.(1207090_1207091) c.(178_177) p.Y60fs RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.(1207090_1207091) c.(178_177) p.Y60fs RefSeq GRCh38/hg38
NM_000455.4 chr19:g.(1207090_1207091) c.(178_177) p.Y60fs RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.(1207090_1207091) c.(178_177) p.Y60fs RefSeq GRCh38/hg38
NM_000455.5 chr19:g.(1207090_1207091) c.(178_177) p.Y60fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
STK11 Y60fs loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor