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Gene FBXW7
Variant G378Dfs*6
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions FBXW7 G378Dfs*6 indicates a shift in the reading frame starting at amino acid 378 and terminating 6 residues downstream causing a premature truncation of the 707 amino acid Fbxw7 protein (UniProt.org). G378Dfs*6 has not been characterized however, due to the effects of other truncation mutations downstream of G378 (PMID: 30510140, PMID: 24838835), is predicted to lead to a loss of Fbxw7 protein function.
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 inact mut FBXW7 G378Dfs*6

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Transcript NM_033632.3
gDNA chr4:g.152329776delC
cDNA c.1133delG
Protein p.G378Dfs*6
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047415901.1 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152329776delC c.1133delG p.G378Dfs*6 RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References