Gene Variant Detail

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Gene NRAS
Variant A59T
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions NRAS A59T lies within the GTP-binding domain of the Nras protein (UniProt.org). A59T has not been characterized, but can be predicted to lead to a gain of Nras function based on the effects of HRAS A59T, which results in increased nucleotide exchange rate and transformation of cultured cells (PMID: 21779495, PMID: 3004741).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS A59T

NRAS mutant NRAS exon3 NRAS A59X NRAS A59T

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Transcript NM_002524.5
gDNA chr1:g.114713915C>T
cDNA c.175G>A
Protein p.A59T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114713915C>T c.175G>A p.A59T RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713915C>T c.175G>A p.A59T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References