PIK3CA I102_E103delinsK
Gene Variant Detail

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Gene PIK3CA
Variant I102_E103delinsK
Impact List indel
Protein Effect unknown
Gene Variant Descriptions PIK3CA I102_E103delinsK results in a deletion of two amino acids in the PI3K-ABD domain of the Pik3ca protein from amino acids 102 to 103, combined with the insertion of a lysine (K) at the same site (UniProt.org). I102_E103delinsK has been identified in sequencing studies (PMID: 30393068, PMID: 33083132), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Mar 2026).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA I102_E103delinsK

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Transcript NM_006218.4
gDNA chr3:g.179199130_179199132delTTG
cDNA c.305_307delTTG
Protein p.I102_E103delinsK
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179199130_179199132delTTG c.305_307delTTG p.I102_E103delinsK RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179199130_179199132delTTG c.305_307delTTG p.I102_E103delinsK RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179199130_179199132delTTG c.305_307delTTG p.I102_E103delinsK RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179199130_179199132delTTG c.305_307delTTG p.I102_E103delinsK RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179199130_179199132delTTG c.305_307delTTG p.I102_E103delinsK RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References