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Gene PIK3CA
Variant L436_P449dup
Impact List duplication
Protein Effect unknown
Gene Variant Descriptions PIK3CA L436_P449dup indicates the insertion of 14 duplicate amino acids, leucine (L)-436 through proline (P)-449, in the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). L436_P449dup has been identified in sequencing studies (PMID: 30393068), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA L436_P449dup

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Transcript NM_006218.4
gDNA chr3:g.179210240_179210281
cDNA c.1306_1347
Protein p.L436_P449
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.5 chr3:g.179210240_179210281 c.1306_1347 p.L436_P449 RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210240_179210281 c.1306_1347 p.L436_P449 RefSeq GRCh38/hg38
NM_006218 chr3:g.179210282_179210283insTTGTAAGCGGTAAGATGGCACTTAACCTTTGGCCTGTACCTC c.1348_1349insTTGTAAGCGGTAAGATGGCACTTAACCTTTGGCCTGTACCTC p.L436_P449dup RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References