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Gene PIK3CA
Variant L455_G460delinsF
Impact List indel
Protein Effect unknown
Gene Variant Descriptions PIK3CA L455_G460delinsF results in a deletion of six amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 455 to 460, combined with the insertion of a phenylalanine (F) at the same site (UniProt.org). L455_G460delinsF has been identified in sequencing studies (PMID: 35242279), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA L455_G460delinsF

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Transcript NM_006218.4
gDNA chr3:g.179210299_179210313del15
cDNA c.1365_1379del15
Protein p.L455_G460delinsF
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894.2 chr3:g.179210299_179210313del15 c.1365_1379del15 p.L455_G460delinsF RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210299_179210313del15 c.1365_1379del15 p.L455_G460delinsF RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210299_179210313del15 c.1365_1379del15 p.L455_G460delinsF RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210299_179210313del15 c.1365_1379del15 p.L455_G460delinsF RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210299_179210313del15 c.1365_1379del15 p.L455_G460delinsF RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References