Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene RAD51C
Variant P21A
Impact List missense
Protein Effect no effect
Gene Variant Descriptions RAD51C P21A lies within a region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). P21A binds to Rad51b, Rad51d, and Xrcc3 to similar levels of wild-type protein in a yeast assay and demonstrates homologous recombination activity similar to wild-type Rad51c in cultured cells (PMID: 36099300).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C P21A

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_058216.3
gDNA chr17:g.58692704C>G
cDNA c.61C>G
Protein p.P21A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722001.4 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References