Gene Variant Detail

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Gene RAD51C
Variant Y224H
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions RAD51C Y224H does not lie within any known functional domains of the Rad51c protein (UniProt.org). Y224H binds to Rad51b, Rad51d, and Xrcc3 at similar levels as wild-type Rad51c in a yeast assay (PMID: 36099300) and therefore, is predicted to have no effect on Rad51c protein function.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C Y224H

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Transcript NM_058216.3
gDNA chr17:g.58703294T>C
cDNA c.670T>C
Protein p.Y224H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047436505.1 chr17:g.58703294T>C c.670T>C p.Y224H RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58703294T>C c.670T>C p.Y224H RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58703294T>C c.670T>C p.Y224H RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58703294T>C c.670T>C p.Y224H RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58703294T>C c.670T>C p.Y224H RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58703294T>C c.670T>C p.Y224H RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58703294T>C c.670T>C p.Y224H RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries