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Gene CDK12
Variant S133Kfs*24
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions CDK12 S133Kfs*24 indicates a shift in the reading frame starting at amino acid 133 and terminating 24 residues downstream causing a premature truncation of the 1490 amino acid Cdk12 protein (UniProt.org). S133Kfs*24 has not been characterized, however, due to the effects of other truncation mutations downstream of S133 (PMID: 24554720, PMID: 25712099), is predicted to lead to a loss of Cdk12 protein function.
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 inact mut CDK12 S133Kfs*24

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Transcript NM_016507.4
gDNA chr17:g.39462468dupA
cDNA c.397dupA
Protein p.S133Kfs*24
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011524898.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_017024753.3 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_017024752.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436264.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436253.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436255.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524906.3 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436259.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524903.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436281.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436288.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436277.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436257.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436283.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524901.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524893.3 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436263.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524896.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524899.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524894.3 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_017024751.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436272.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436285.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524900.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436290.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524892.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436268.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436261.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_017024753.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436280.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436286.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436276.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436256.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524897.3 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524907.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
NM_016507.3 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_005257458.4 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436279.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436273.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524907.3 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_017024750.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436258.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524895.3 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524895.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436262.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436282.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436267.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524897.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
NM_015083.4 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524906.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436278.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524893.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436284.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_024450801.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436260.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524894.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524905.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436275.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_017024749.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_017024747.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436269.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_005257456.5 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436292.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_005257456.4 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436293.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524898.3 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_011524902.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436291.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
NM_015083.2 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_017024748.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
NM_016507.4 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436265.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436266.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436289.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436274.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436270.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38
XM_047436287.1 chr17:g.39462468dupA c.397dupA p.S133Kfs*24 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
CDK12 S133Kfs*24 loss of function - predicted Olaparib