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Gene RAD51C
Variant F103V
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RAD51C F103V lies within the region required for Holliday junction resolution activity and the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). F103V results in decreased interaction with Rad51b, Rad51d, and Xrcc3 in a yeast assay and reduced homologous recombination activity in cultured cells (PMID: 36099300).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C F103V

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Transcript NM_058216.3
gDNA chr17:g.58695092T>G
cDNA c.307T>G
Protein p.F103V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722001.4 chr17:g.58695092T>G c.307T>G p.F103V RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58695092T>G c.307T>G p.F103V RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695092T>G c.307T>G p.F103V RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695092T>G c.307T>G p.F103V RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58695092T>G c.307T>G p.F103V RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58695092T>G c.307T>G p.F103V RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695092T>G c.307T>G p.F103V RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58695092T>G c.307T>G p.F103V RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695092T>G c.307T>G p.F103V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References