Gene Variant Detail

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Gene RAD51C
Variant G112V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C G112V lies within the region required for Holliday junction resolution activity and the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). G112V results in decreased interaction with Rad51b, Rad51c, and Xrcc3 in a yeast assay (PMID: 36099300), but has not been fully biochemically characterized and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C G112V

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Transcript NM_058216.3
gDNA chr17:g.58695120G>T
cDNA c.335G>T
Protein p.G112V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002876.3 chr17:g.58695120G>T c.335G>T p.G112V RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58695120G>T c.335G>T p.G112V RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695120G>T c.335G>T p.G112V RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58695120G>T c.335G>T p.G112V RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58695120G>T c.335G>T p.G112V RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695120G>T c.335G>T p.G112V RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695120G>T c.335G>T p.G112V RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58695120G>T c.335G>T p.G112V RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695120G>T c.335G>T p.G112V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries