RAD51C Q133K
Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene RAD51C
Variant Q133K
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RAD51C Q133K lies within the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). Q133K results in decreased interaction with Rad51b, Rad51d, Xrcc3, and DNA in in vitro assays, decreased ATPase activity in an in vitro assay, and reduced homologous recombination activity compared to wild-type Rad51c in cultured cells (PMID: 36099300).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C Q133K

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_058216.3
gDNA chr17:g.58695182C>A
cDNA c.397C>A
Protein p.Q133K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047436505.1 chr17:g.58695182C>A c.397C>A p.Q133K RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58695182C>A c.397C>A p.Q133K RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58695182C>A c.397C>A p.Q133K RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58695182C>A c.397C>A p.Q133K RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695182C>A c.397C>A p.Q133K RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695182C>A c.397C>A p.Q133K RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695182C>A c.397C>A p.Q133K RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695182C>A c.397C>A p.Q133K RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58695182C>A c.397C>A p.Q133K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References