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Gene RAD51C
Variant T132P
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RAD51C T132P lies within the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). T132P retains binding to Rad51b, Rad51c, and Xrcc2 but not Xrcc3 in an in vitro assay in one study (PMID: 33832919), but demonstrates reduced interaction with Rad51b, Rad51d, and Xrcc3 in a yeast assay in another study (PMID: 36099300), results in undetectable interaction with DNA in in vitro analyses, reduced homologous recombination activity compared to wild-type Rad51c in cultured cells (PMID: 36099300, PMID: 33832919), fails to rescue survival of Rad51c-null cells, and results in decreased Rad51 foci formation in cell culture (PMID: 33832919).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C T132P

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Transcript NM_058216.3
gDNA chr17:g.58695179A>C
cDNA c.394A>C
Protein p.T132P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722002.4 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
RAD51C T132P loss of function Olaparib