Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene RAD51C
Variant T132P
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RAD51C T132P lies within the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). T132P retains binding to Rad51b, Rad51c, and Xrcc2 but not Xrcc3 in an in vitro assay in one study (PMID: 33832919), but demonstrates reduced interaction with Rad51b, Rad51d, and Xrcc3 in a yeast assay in another study (PMID: 36099300), results in undetectable interaction with DNA in in vitro analyses, reduced homologous recombination activity compared to wild-type Rad51c in cultured cells (PMID: 36099300, PMID: 33832919), fails to rescue survival of Rad51c-null cells, and results in decreased Rad51 foci formation in cell culture (PMID: 33832919).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C T132P

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_058216.3
gDNA chr17:g.58695179A>C
cDNA c.394A>C
Protein p.T132P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047436505.1 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58695179A>C c.394A>C p.T132P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C T132P Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, Lynparza (olaparib) treatment resulted in decreased survival of cells expressing RAD51C T132P in culture (PMID: 33832919). 33832919
RAD51C T132P ovarian cancer sensitive Cisplatin + Paclitaxel Case Reports/Case Series Actionable In a clinical case study, treatment with Platinol (cisplatin) plus Taxol (paclitaxel) following surgery resulted in a response with a progression-free survival of at least 10 years in a patient with ovarian cancer harboring RAD51C T132P, and preclinical studies demonstrated cells expressing RAD51C T132P were sensitive to Platinol (cisplatin) in culture (PMID: 33832919). 33832919